The Countdown - or rather the count UP.

Sep 26th 1396 - Sultan Bajezid I beheads 100s of crusaders and reincarnates in 2014 and beheads a Southampton Moderator.

 

Blimey! I had better tell Qwerty to keep an eye out!

 

1397- Geoffrey Chaucer tells the Canterbury Tales for the first time at the court of Richard II.
This work spawned an incredible interest in the grinding of wheat to make flour.

 

Henry 4th 1399-1413 (Aged 32 when crowned) House of Lancaster
The first Lancastrian King with dubious claims to the throne, some 8th in line, who took the throne by force from Richard.
Henry previously known as Bolingbroke after Bolingbroke Castle where he was born and then later the Duke of Lancaster, was the same age as his predecessor and cousin Richard who Henry murdered by starvation. This haunted him throughout his reign both through guilt and through the many English enemies he made by taking the crown by military force. Richard had been the eldest son of the Black Prince who himself was the eldest son of Edward 3rd. Bolingbroke or Henry 4th was only the eldest surviving son of John of Gaunt who had been Edward 3rd ‘s third son. A third man or actually a boy was Edmund Mortimer, the 5th Earl of March, was next in line after Richard being the great grand son of Lionel, Edward 3rd ‘s second son.

Todays diary was on post 1395 which was overtaken in dealing with CF

 

The IBM 1401 was a variable wordlength decimal computer that was announced by IBM on October 5, 1959. The first member of the highly successful IBM 1400 series, it was aimed at replacing electromechanical unit record equipment for processing data stored on punched cards. Over 10,000 units were produced and many were leased or resold in less developed countries after they were replaced with newer technology. The 1401 was withdrawn on February 8, 1971.

A sunny good morning from here Woopert - if weather forecasters were paid on performance they would be penniless - hope for your sake it clears up - Poch still keeping the seat warm so heres hoping - ATB

 

Battlefield 1403 a part of the Albrighton Estate
A range of traditional farm buildings on one of the estate farms have been converted into our newest enterprise. Opened in April 2008 and now employing 35 people, it consists of a farm shop and butchery, cafe, battlefield exhibition and falconry centre.
The estate supplies the butchery with home reared beef and lamb. In the summer months, the cattle and sheep can be seen up close, grazing in paddocks surrounding the buildings.
At Battlefield 1403 our aim is to create a happy, relaxed & popular visitor destination where everyone feels welcome.

If he can keep the majority of his squad then he might stay it would be interesting what input Cortese has in this as he brought him to St Marys and he is in the background - as for cherrypicking that is always a worry

 

Mobil Vacuoline 1405 is an extra high performance lubricant designed for machine tools that use one oil for both hydraulic systems and way lubrication. It is formulated with high quality mineral base oils and a unique additive technology that provides excellent lubricity properties to eliminate stick-slip and chatter of heavily loaded and vertical box ways. This product meets the low frictional properties required to assure acceptable production levels of quality parts with minimum downtime in today’s high output machine tools.

FECK ! Sids gone - Saturday dawns sunny again with a temp of 26 forecast which is madness for 7 days before winter - still no announcement from St Marys - we are Doomed I tell you Doomed - avagoodweekend

 

Nov 20th 1407 - A truce between John the Fearless, Duke of Burgundy and Louis of Valois, Duke of Orléans is agreed under the auspices of John, Duke of Berry. Orléans would be assassinated three days later by Burgundy.

We have a Pay Channel called UK TV we get the lot Ted Yes Min. Yes P.M. The Sweeney Lewis Midsomer Murders Only Fools etc etc

 

Isabelle of France (1389-1409), oldest daughter of King Charles VI, was not quite seven years old when she married Richard II as his second wife in 1396. He seems to have been very kind to her. In the Middle Ages princely and aristocratic marriages were often contracted on behalf of young children for reasons of diplomacy or for other material advantages. Canon law, however, decreed that such marriages should not be consummated until both parties were of age, at least twelve for a girl and fourteen for a boy.

Good Evening Woopert - threat of precipitation in the air this a.m. - Harrys lot up again with their debt should be interesting - hope its cleared for your bank holiday ATB

 

1411 has the property that the sum of its divisors (excluding 1 and itself) is a square (A187086): 17 + 83 = 100 = 102.

Well I never - fancy that

 

TGN1412 (also known as CD28-SuperMAB) is the working name of an immunomodulatory drug which was withdrawn from development after inducing severe inflammatory reactions in the first-in-man study in London in March 2006.[1] The developing company, TeGenero Immuno Therapeutics, entered into insolvency proceedings later that year.

Originally intended for the treatment of B cell chronic lymphocytic leukemia (B-CLL) and rheumatoid arthritis,[2] TGN1412 is a humanised monoclonal antibody that not only binds to, but is a strong agonist for, the CD28 receptor of the immune system's T cells.[3] CD28 is the co-receptor for the T cell receptor; It binds to receptors on the interacting partner in the reaction through one of its ligands (B7 family).

In its first human clinical trials, it caused catastrophic systemic organ failure in the subjects, despite being administered at a supposed sub-clinical dose of 0.1 mg per kg; some 500 times lower than the dose found safe in animals.[4] Six volunteers were hospitalized on 13 March 2006, at least four of these suffering from multiple organ dysfunction. Tentative opinions from an as-yet uncompleted inquiry suggest that the problems resulted from "unforeseen biological action in humans", rather than breach of trial protocols, and the case therefore has had important ramifications for future trials of potentially powerful clinical agents.

Scientists in early 2007 put forth the theory that the drug acted in a different fashion in humans as compared with the laboratory animals in which the drug was first tried. The severe reactions in humans could have only occurred, they believe, in animals with memory T lymphocytes. Animals raised in a sterile lab would presumably have no 'memory' of previous illnesses, thus would not exhibit the severe reactions that occurred in the human subjects.[5] However this is a misunderstanding of the research: the research says that non-human animals studied have fewer memory T cells than humans, and that stimulation through the CD28 receptor alone in memory T cells causes them to infiltrate organs and also activates them.[6]