We've only lost 1 league game in the 12 since the last derby (3-2 away at Spuds)
The loss of Coleman is a huge blow, and we've now lost Funes Mori who was stretchered off for Argentina last night
Lallana makes you tick and so his loss is huge imo, but it's Mane I see as being your key man, plus Coutinho carries a goal threat if allowed space around the box.
The key for us is having the composure to play through your high press, and not simply hitting the channels, we need to mix it up and use both methods of getting at your back line.
With Mori out, we'll be vulnerable in the air, so set pieces could be our undoing here.
I think Koeman could well opt for a back 3 given the injuries, with the possibility of young Kenny getting his chance at RWB.
Overall if Schneiderlin is fit then I think we've got a decent chance, if it's Barry in that role, I think we'll end up getting rolled over.