I'm having quite a bit of luck playing with an ancorman, 2 midfielders, 2 wingers and a quick striker. I had a fair bit of success in the championship with an Adkins-style 442/424, but the PL teams just play through you if you do that. Also JWP has turned really good for my first season up.
He's tearing it up for me atm. Two deeper players behind him are still Morgan and Corky, with Delph, David Vaughan and Matt James as back up