Unfortunately, I can't see Murray beating Nole.
The pressure in my opinion is all on Murray. He's yet to win a Grand Slam, and with Nadal and Federer both out, there's a huge expectation on him to wrap up his first. Nole has already won a Grand Slam, so knows what it takes to win one.
Besides, I just don't think Murray can beat Nole in the sort of form he's in. Murray will be playing against someone who can reach and get to everything just as well as he can. As good a returner as Murray is, Nole's serving is back to it's very best and knowing how good Nole is at returning, I can't see Murray's serve being good enough. He'll be broken just as often as he holds I reckon.
Heart says Muzza, head says Nole.