Aquatic species that live in great depths would encounter humans very rarely. Large species that are "discovered" on land are usually just reclassification of existing species in the 21st C. (One species being reclassified as two). No chance Bigfoot exists. Not just no evidence. No evidence of ancestors. Not one fossil of a bipedal mammal in North America. There has been no species discovered in fossil record that could be a Bigfoot ancestor. Its not 20thC anymore. We have drones. Satellites. Automatic cameras are cheap. DNA sequencing is cheap to test droppings and fur. Everywhere is close to man. So many people actively looking for it. A cryptid in Africa or Asia. Maybe. Not in Europe or North America like Bigfoot. I'd give Asia's YetI a 0.01% chance of existing but America's Bigfoot 0%.
I think the investigative programme someone mentioned above showed that the Yeti was a bear, but a sort of hybrid Brown/Polar bear. DNA of hair samples offered as evidence came up with both species.