Douglas Ferguson, a surgeon at Exeter Hospital, said it was the government's responsibility to protect the population, describing the policy as "quite sensible".
"I think, to be honest, if people who don't want to be vaccinated feel that an injection, which is very well scientifically researched, is something that they decide they're going to change their entire career for, it seems unwise, I would say."
Overall, Mr Ferguson thought the move was likely to be welcomed by staff.
"If all the staff know everybody else is vaccinated - I mean the majority are already anyway - I think it would give further confidence in you doing your job and potentially from those members of staff also."
He added that he only knew of one colleague who had chosen not to be vaccinated.
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In the NHS, more than 92% of frontline staff have had their first dose and 89% are fully vaccinated - higher than the general working-age population, where about 81% have had both doses.