Yep! KERS would absolutely love four wheel drive, especially if most of the energy could be harvested from the front wheels, and then delivered from the rear. This would balance the tyre wear far more between front and rear wheels, but of course would require a significant change in a car's weight distribution, as well as reducing its top speed, since all transmissions of power involve losses. Then again, four wheel drive would further increase cornering speeds once a balance is found, probably resulting in cars pulling a crazy (and rather unhealthy) 6G!