Cyc, whilst I can't think of any off the top of my head, I do know of some fillies and mares that have been discovered to have things like ovarian tumours which cause high levels of testosterone. It is usually noticed due to particularly aggressive tendencies in the affected mares.
Certainly there is a school of thought that very good race mares are often failures in the breeding shed, the high levels of testosterone that give them the competitive edge often resulting in lost pregnancies, weak foals, etc. Look at Soviet Song: she was retired to stud in 2007 and in the following eight years before her death (in November 2015) produced just three foals, one of which died shortly after birth in 2015. Her only runner to date was an Oasis Dream gelding called Soviet Dream who finished last on each of his two starts. She has a two year old filly by Speightstown who is yet to be named.