The Championship club,
docked 12 points for entering administration in September, have agreed to the dismissal of their appeal against that decision.
The latest penalty leaves Wayne Rooney's side on -3 points - 18 points from safety at the foot of the table.
It means the Rams are almost certain to be relegated to League One.
Derby have also been given a further suspended three-point deduction for their breaches of the league's profitability and sustainability (P&S) rules.
That will take effect if the Rams fail to comply with the terms of a budget for the remainder of the season set out as part of an 'agreed decision' between the EFL and the club.
Carl Jackson, from Derby's administrators Quantuma, said: "This has been a difficult matter to navigate bearing in mind the various issues concerned.
"Whilst point deductions are never ideal, it was critical to the club's future that all matters were concluded between the EFL and the club in relation to historical issues.
"This conclusion allows us to proceed with our restructuring strategy for the club with prospective interested parties."
Derby have only spent four seasons outside the top two divisions of English football in their entire history.
The last occasion was in 1985-86, when they were promoted under Arthur Cox.