Reina and Downing for me. Both nailed on starters. Also a sneaky suspicion that Andy Carroll will score plenty this season.
Id say best players to pick would be Johnson,Suarez,Downing,Kuyt ( who I predict will play nearly every game despite the signings made in the last 6 months)
Downing is a great shout, and then transfer Suarez in when he is ready to start which I suspect will be 2nd game against Arsenal.