Good question. One that's effective and that doesn't stop sites you are using from working normally. I've only dabbled with them and quickly given up because sites wouldn't work as normal with the ad blocker on.
On FireFox browser I use - AdBlock+, Ghostery and Privacy Badger Any issues with page not working just pause the offending app whilst you are done.
You might like to use the Duckduckgo browser. Privacy covered and no adverts on Youtube videos and you can block other adverts. https://thedroidguy.com/how-can-i-block-ads-while-using-duckduckgo-1265992
Google Chrome seems to have had a major crackdown on adblockers (slightly understandable as that's the whole premise of their empire), so if you use that, you might be a bit **** out of luck. I use the Firefox browser with uBlock Origin and it works flawlessly.
I use DuckDuckGo and it is very good. If any problems switch to Safari with DuckDuckGo as my search engine with adblock+ on.
As a poster says below Adblock+ is pretty decent. Doesn’t stop many things working, at least on Safari Also, as another poster says using DuckDuckGo as your browser is effective. Both methods stooped the constant popups on sites like the HDM which previously made it unreadable.
On my phone I’ve got AdBlock Pro, makes reading HDM actually readable without jumping all over the place.