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Coronavirus. Just Coronavirus.

Discussion in 'General Chat' started by GroveRanger, Jan 23, 2020.

  1. Gambol

    Gambol George Clooney's wee brother

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    No chance. They'll have to prise my meat from my cold dead hands.
     
    #17861
    Archers Road likes this.
  2. YourIdiotSon

    YourIdiotSon Well-Known Member

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    I genuinely believe we will all be vegan, not through choice , by 2050.
     
    #17862
  3. Easter Road 1980

    Easter Road 1980 Well-Known Member

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    Olive Oil typewriters?

    Hmmm, interesting.
     
    #17863
  4. DMD

    DMD Eh?
    Forum Moderator

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    I don't think corpses can be vegan. :emoticon-0104-surpr
     
    #17864
    YourIdiotSon likes this.
  5. DMD

    DMD Eh?
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    #17865
    YourIdiotSon likes this.
  6. YourIdiotSon

    YourIdiotSon Well-Known Member

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    Apologies , you will be the second course for the elite .
     
    #17866
    DMD likes this.
  7. Gambol

    Gambol George Clooney's wee brother

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    At a Donner party?
     
    #17867
    YourIdiotSon likes this.
  8. YourIdiotSon

    YourIdiotSon Well-Known Member

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    The Andes is a bit far to travel for most .
     
    #17868
    Gambol likes this.
  9. DMD

    DMD Eh?
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    please log in to view this image
     
    #17869
    DUNCAN DONUTS and YourIdiotSon like this.
  10. YourIdiotSon

    YourIdiotSon Well-Known Member

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    the amount of FDA employees who come from or move onto ‘big pharma’ is scandalous.
     
    #17870
    DMD likes this.

  11. Erik

    Erik Well-Known Member

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    That's because Mr Nadal has proven his loyalty to The Cause™ by taking Ze Jab©
     
    #17871
    DMD likes this.
  12. DMD

    DMD Eh?
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    There's an interesting story from the US about Ivermectin. The Health insurance companies have sent communications to the doctors on their panels to cease from prescribing Ivermectin even off label, which means unathourised use but remains perfectly legal if safe to use. Now this breaches the terms and conditions that the Health Insurance have with the doctors. Their licence and agreement with the doctors states that they will not interfere with the doctor patient relationship including the prescribing of drugs. They have unilaterally altered the terms and condtions to say "except for the prescription of ivermectin". If they find out that the doctor has subsequently prescribed Ivermectin then they risk sanctions including exclusion.

    Now the new kid on the block is Pfizer's Paxlovid, which is two drugs, nirmatrelvir and ritonavir, The dose is 3 pills for 5 days. The eye watering costs is 700 dollars a dose. Paxlovid is a protease inhibitor and is patented by Pfizer which will last 20 years. Its been rushed through approval by the FDA. Its use is for those suffering symptoms but before hospitilisation within 5 days.

    Ivermectin is cheap. The patent from Pfizer has run out. There is so much misinformation about this drug. E.g. anti parasite for animals but it has been used millions of times in humans for treatment of scabies.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/
    Conclusion
    Developing an effective therapeutic against COVID-19 is currently the utmost interest to the scientific communities. The present study depicts comparative binding efficacy of a promising FDA-approved drug, ivermectin, against major pathogenic proteins of SARS-CoV-2 and their human counterparts involved in host–pathogen interaction. Herein, our in silico data have indicated that ivermectin efficiently utilizes viral spike protein, main protease, replicase and human TMPRSS2 receptors as the most possible targets for executing its antiviral efficiency. Therefore, ivermectin exploits protein targets from both virus and human, which could be the reason behind its excellent in vitro efficacy against SARS-CoV-2 as reported by Caly et al. [13]. Ivermectin B1b isomers have been found to be the more efficacious molecule out of the two homologs. Intriguingly, comparison of the in silico efficiency of ivermectin with currently used anticorona drugs, such as hydroxychloroquine and remdesivir, indicated toward the potential of ivermectin to target the major pathogenic proteins of SARS-CoV-2. Ivermectin is a popular antiparasitic drug and is also safe in children, younger adults, pregnant and lactating ladies. Development of pulmonary delivery of ivermectin through synthesis of better ivermectin formulation has been reported recently and this is expected to shorten the treatment duration and lead to better outcomes [33]. It is noteworthy to mention that many anti-SARS-CoV-2s are now being tested for their efficacy in shaping the immune response of humans, through targeting the cell surface as well as intracellular toll-like receptors [34,35]. In this context, ivermectin could be an effective option as well. Considering all these facts, the present study explores the therapeutic targets of ivermectin against SARS-CoV-2 and enlightens the possibility of using this drug in COVID-19 clinical trials shortly.
     
    #17872
    YourIdiotSon likes this.
  13. DUNCAN DONUTS

    DUNCAN DONUTS SOCIAL JUSTICE WARRIOR

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    #17873
  14. Gambol

    Gambol George Clooney's wee brother

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    I never believed in coincidence until now.
     
    #17874
    YourIdiotSon, EDGE. and DMD like this.
  15. Archers Road

    Archers Road Urban Spaceman

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    That's weird, neither did I...
     
    #17875
    Ron, YourIdiotSon, DMD and 1 other person like this.
  16. DUNCAN DONUTS

    DUNCAN DONUTS SOCIAL JUSTICE WARRIOR

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  17. DUNCAN DONUTS

    DUNCAN DONUTS SOCIAL JUSTICE WARRIOR

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    Morons

     
    #17877
    EDGE. likes this.
  18. Gambol

    Gambol George Clooney's wee brother

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    I thot James Whale was deid?
     
    #17878
    Ciaran likes this.
  19. QuarterMoonII

    QuarterMoonII Economist

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    Are you predicting that you will die masturbating but they will not discover your corpse for a couple of days?
     
    #17879
    Gambol likes this.
  20. DUNCAN DONUTS

    DUNCAN DONUTS SOCIAL JUSTICE WARRIOR

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    I think I had Umnicorn coughing white gelatinous phlegm and hangover like symptoms.

    You get it ?
     
    #17880

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