Never underestimate the danger of underestimating the opponent. Get the game under control, then rest players - don't rest them from the start then have to throw them on in desperation if it all goes tits up.
We can use 5 subs as well so we can always start strong and then take the players off - similar to what we did vs Ajax .
Nah, I'm with Saint; strong first eleven and win the game. Make changes (up to five of them!) later if we're in a position to do so