Nanotech. Wee nanobots that destruct matter to push the molecules around to make other matter will go nuts and destruct everything.
Depends on the growth rate of Mick's foot. At current speeds it's predicted to block out the sun by 2035.
1-Trump with his " Dennis The Menace " button problem . 2-Non computer virus 3 Global warming 4- Losing the ability to reproduce 5- Nukes 6- A big ass asteroid 7- Food and water ruined 8- Alien takeover 9- Angry God 10- Stampeding elephants 11- Earth loses it's orbit 12- Man and woman loses the ability to crap